NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 uM. The IC50 values are 3.0-5.0 uM for human platelet 12-LO and 0.91 uM for rabbit reticulocyte 15-LO.
产品描述
NDGA is a non-selective lipoxygenase inhibitor which blocks CysLT synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 uM.{346} The IC50 values are 3.0-5.0 uM for human platelet 12-LO and 0.91 uM for rabbit reticulocyte 15-LO.{346,1462}