Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally， indomethacin is a substituted indole acetic acid， wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example， the IC50 for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 uM， making it more than 1，700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC50 of 0.05 uM for the inhibition of COX-2， it also inhibits COX-1 with a corresponding IC50 of 0.67 uM.
产品描述
A potent， non-selective COX-2 inhibitor （IC50 = 0.04 uM）； >1，700 times more potent as an inhibitor of COX-2 than COX-1
