Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue，suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
This Cyclin E1 antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin E1. The exact sequence is proprietary.
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠、牛、狗、猪种属来源的Cyclin E1蛋白发生免疫反应.
保存建议
提供的Cyclin E1抗体为无色溶液形式，产品浓度为1 mg/ml，溶解于包含有100 mM glycine与海藻糖的50 mM Tris缓冲液（pH 7.0）.请在收到该Cyclin E1抗体产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.
