HP1 alpha，beta and gamma are components of heterochromatin. They recognize and bind histone H3 tails methylated at ‘Lys-9’，leading to epigenetic repression of transcription. HP1 alpha，beta and gamma also interact with lamin B receptor （LBR），thereby contributing to the association of heterochromatin with the inner nuclear membrane.
应用类型
Western Blot: 1:1000， IF: 1:500， ChIP: 4 ug/ChIP
免疫原
Polyclonal antibody raised in rabbit against human HP1 B （Heterochromatin protein 1 homolog beta）， using the full length recombinant GST tagged protein. The antibody also recognizes the and γ isoforms.
