CBX5/HP1 alpha is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at ‘Lys-9’，leading to epigenetic repression of transcription. HP1 alpha may also interact with lamin B receptor （LBR），thereby contributing to the association of the heterochromatin with the inner nuclear membrane. Further，HP1 alpha is involved in the formation of a functional kinetochore through interaction with MIS12 complex proteins.
应用类型
Western Blot: 1:1000， IF: 1:500
免疫原
Polyclonal antibody raised in rabbit against human HP1 （Heterochromatin protein 1 homolog alpha）， using the full length recombinant GST tagged protein.
