JARID1b is a histone demethylase which specifically demethylates mono-，di，and trimethylated lysine 4 of histone H3. It acts as a transcriptional repressor for the tumor suppressor genes BRCA1 and HOXA5 and has been associated with breast cancer development. In contrast，in melanoma JARID1b itself may function as a tumor suppressor.
应用类型
Western Blot: 1:500， ELISA: 1:100 – 1:200.
免疫原
Polyclonal antibody raised in rabbit against mouse Jarid1b （Jumonji， AT rich interactive domain 1B）， using a KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein.
