EZH2 is a histone-lysine methyltransferase which methylates ‘Lys-9’ and ‘Lys-27’ of histone H3，leading to transcriptional repression. It is a member of the polycomb group （PcG） family which form multimeric protein complexes and are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The EZH2 activity is dependent on the association with other components of the PRC2 complex （EED，EZH2，SUZ12/JJAZ1，RBBP4 and RBBP7）. EZH2 may play a role in the hematopoietic and central nervous systems. Over-expression of EZH2 is observed during advanced stages of prostate cancer and breast cancer.
应用类型
ChIP: 2.5 ug/ChIP， Western Blot: 1:1000， IHC: 1:100 – 1:500.
免疫原
Polyclonal antibody raised in rabbit against the N-terminus （aa1-343） of the mouse EZH2 protein （Enhancer of zeste homolog 2）.
