Ash2 is a component of the Set1/Ash2 histone methyltransferase （HMT） complex. This complex specifically methylates K4 of histone H3，thereby activating transcription. Methylation of K4 is blocked by premethylation of the neighboring K9，a repressor of transcription. This indicates that the Set1/Ash2 HMT complex mediates the crosstalk between K9 methylation and K4 methylation. Ash2 plays a role in hematopoiesis and may be associated with some kinds of leukemia.
Polyclonal antibody raised in rabbit against mouse Ash2 （absent， small， or homeotic 2）， using 3 different KLH-conjugated synthetic peptides， 2 containing an amino acid sequence from the central and 1 containing an amino acid sequence from the C-terminal part of the protein.
