MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases （HDAC’s） and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.
应用类型
ChIP: 1.5 ug/ChIP， WB: 1:500， ELISA: 1:1000.
免疫原
MBD1 （Methyl-CpG-binding domain protein 1） synthetic peptide containing a sequence from the N-terminal conjugated to KLH
