Major histocompatibility complex （MHC） molecules form an integral part of the immune response system. They are cell-surface receptors that bind peptides and present them to T lymphocytes. Human leukocyte antigens （HLAs） are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I （HLA-A，HLA-B and HLA-C） and class II （HLA-D）. Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A encodes a membrane anchored heavy chain which hetero-dimerizes with a light chain （b-2-Microglobulin） to form MHC-I. Polymorphisms yield hundreds of HLA-A alleles.
应用类型
WB: 1:500 – 1:1000.
免疫原
This HLA-A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from human HLA-A.
