OCT4 （OCT3） Antibody （POU5F1； OCT3； OCT4； OTF3； POU domain， class 5， transcription factor 1； Octamer-binding protein 3； Octamer-binding protein 4； Octamer-binding transcription fac
Oct-4 （POU5F1） is a transcription factor highly expressed in undifferentiated embryonic stem cells and embryonic germ cells. A network of key factors that includes Oct-4，Nanog，and Sox2 is necessary for the maintenance of pluripotent potential，and downregulation of Oct-4 has been shown to trigger cell differentiation. Research studies have demonstrated that Oct-4 is a useful germ cell tumor marker. Oct-4 exists as two splice variants，Oct-4A and Oct-4B. Recent studies have suggested that the Oct-4A isoform has the ability to confer and sustain pluripotency，while Oct-4B may exist in some somatic，non-pluripotent cells.
应用类型
Western blot: ~1:1000， IF: ~1:10–1:50.
免疫原
This OCT4 （OCT3） antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-141 amino acids from human OCT4 （OCT3）.
