Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor （NGF），originally discovered in the 1950s as a soluble peptide promoting the survival of，and neurite outgrowth from，sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor （BDNF），neurotrophin-3 （NT-3） and neurotrophin-4 （NT-4） （also designated NT-5）. These various neurotrophins stimulate the in vitro survival of distinct，but partially overlapping，populations of neurons. The cell surface receptors through which neurotrophins mediate their activity have been identified. For instance，the Trk A receptor is the preferential receptor for NGF，but also binds NT-3 and NT-4. The Trk B receptor binds both BDNF and NT-4 equally well，and binds NT-3 to a lesser extent，while the Trk C receptor only binds NT-3.
应用类型
Western blot: ~1:1000， IHC: ~1:10–1:50， IF: ~1:10–1:50， FC: ~1:10–1:50.
免疫原
This BDNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human BDNF.
