Accumulation of the amyloid-beta （Abeta） plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor （APP） at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme （BACE） and aspartyl protease 2 （Asp2）. A BACE homolog was recently cloned and designated BACE2，Asp1，DRAP （for Down region aspartic protease），and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3，the so-called ’Down critical region’，suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
应用类型
Western blot: ~1:1000， IHC: ~1:50-1:100.
免疫原
This BACE2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human BACE2C.
