Proprotein convertase subtilisin/kexin type 9 （PCSK9），is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A （EGF-A） domain of the low-density lipoprotein receptor （LDLR），inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia （HCHOLA3）.
应用类型
WB， IHC-P
免疫原
A synthetic peptide corresponding to a sequence at the C-terminal （671-687aa AVTAVAICCRSRHLAQA） of human PCSK9.
