Androgens exhibit a wide range of effects on the development，maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor （AR） is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone （T） and dihydrotestosterone （DHT）. The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding results in an at least 6-fold increase in androgen receptor stability.
应用类型
Western blot: ~1:1000， IHC: ~1:10-1:50
免疫原
This Androgen Receptor （ANDR） antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor （ANDR）.
