Acetylcholinesterase （AChE） hydrolyzes acetylcholine at synaptic junctions. Alternative mRNA splicing gives rise to three forms of AChE. It plays a role in neuronal apoptosis. The T form，also known as the asymmetric form，is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer’s disease. However，AChE activity is increased around amyloid plaques，which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.
应用类型
Western blot: ~1:1000， FACS: ~1:10–1:50， IHC: ~1:10-1:50， IF: 1:10-1:50.
免疫原
This ACHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the N-terminal region of human ACHE.
