Tyrosyl-DNA phosphodiesterase （TDP1） is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3’ phosphate. This protein is a member of the phospholipase D （PLD） superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spino-cerebellar ataxia with axonal neuropathy （SCAN1） by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.
应用类型
Western blot: ~1:1000 - 2000， ELISA.
免疫原
Recombinant human TDP1 （1-298aa） purified from E. Coli. Anti-human TDP1 mAb， clone AT1F2， is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TDP1 protein.
