N6-methyladenosine （m6A），or methylation of the N6 position of adenosine is a posttranscriptional modification of RNA. Due to a lack of analytical methods，N6-methyladenosine is poorly understood，but new evidence suggests that it is a very common base modification and important physiological regulator. N6-methyladenosine is markedly increased throughout brain development，and is enriched near stop codons，microRNA-binding sites and UTRs，which indicates a fundamental role in the regulation of gene expression. N6-methyladenosine is also highly conserved between human and mouse. The regulation of m6A modifications in mRNA has been linked to disease，where fat mass and obesity-associated （FTO） has been has been reported to be a obesity risk gene. FTO is a m6A demethylase and polymorphisms that result in increased FTO expression are associated with increased body mass and risk of obesity.
应用类型
Western blot: 1-4 ug/ml. Dot Blot， Chromatin Immunoprecipitation （ChIP）， RNA Binding Protein Immunoprecipitation （RIP）.
免疫原
This antibody is generated from rabbits immunized with a BSA conjugated N6-Methyladenosine （BV-N13-14）.
