The phosphatidylinositol （PtdIns） phosphates represent a small percentage of total membrane phospholipids. However， they play a critical role in the generation and transmission of cellular signals. PtdIns-（3，4，5）-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology （PH） domains. Centuarin .alpha. and Akts are examples of PtdIns-（3，4，5）-P3-binding proteins. Protein-binding to PtdIns-（3，4，5）-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-（3，4，5）-P3 is resistant to cleavage by PI-specific PLC. Thus， it is likely to function in signal transduction as a modulator in its own right， rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids， see also references and .
产品描述
A synthetic analog of natural PtdIns featuring C:18 fatty acid in the sn-1 position and arachidonic acid in the sn-2 position of the glycerol backbone； a critical phospholipid species that can served as an anchor for the binding of signal transduction proteins bearing pleckstrin homology （PH） domains
