The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However， they play a critical role in the generation and transmission of cellular signals. PtdIns-（4，5）-P2 incorporated into membrane lipids can bind to important proteins such as Group IV cPLA2 and PLC.delta.1， enhancing their adherence to the membrane and increasing the rate of substrate hydrolysis. PtdIns-（4，5）-P2 can be further phosphorylated to give triphosphates such as PtdIns-（3，4，5）-P3. It can also be cleaved by PI-specific PLC to give inositol triphosphates. The diacyl glycerol and IP3 generated by this PLC-cleavage are also part of a complex biochemical and signal transduction cascade which has not been entirely elucidated. For some additional reading， please see references ， ， and .
产品描述
A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions； contains the same inositol and DAG stereochemistry as the natural compound
