The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However， they play a critical role in the generation and transmission of cellular signals. PtdIns-（3，4，5）-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology （PH） domains. Centuarin .alpha. and the Akt-family of GTPase activating proteins are examples of PtdIns-（3，4，5）-P3-binding proteins. Protein-binding to PtdIns-（3，4，5）-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-（3，4，5）-P3 is resistant to cleavage by PI-specific phospholipase C （PLC）. Thus， it is likely to function in signal transduction as a modulator in its own right， rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids， see also references and .
产品描述
A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions； contains the same inositol and DAG stereochemistry as the natural compound
