LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced through a non-genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential.
序列
重组人LDHA蛋白产品，又称L-lactate dehydrogenase A chain, GSD11, LDH1, LDHM, PIG19.其对应NCBI基因号为3939，对应Accession号为P00338.
来源宿主
提供的【LDHA】重组人LDHA产品的来源为大肠杆菌重组表达.
溶解建议
重组人LDHA产品为液体即用型，其溶液组成为：0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.
