Cyclophilin B is a cyclosporine-binding protein. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. It also bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
序列
重组人亲环蛋白 B 蛋白产品，又称PPIB, Peptidyl prolyl isomerase B, CYPB; SCYLP; CYP-S1.其对应NCBI基因号为5479，对应Accession号为P23284.
来源宿主
提供的【Cyclophilin B 】重组人亲环蛋白 B 产品的来源为大肠杆菌重组表达.
溶解建议
重组人亲环蛋白 B 产品为液体即用型，其溶液组成为：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20 mM NaCl, 0.5 mM DTT, 10% glycerol.
保存建议
在您收到艾美捷发出的【Cyclophilin B 】重组人亲环蛋白 B 产品后，建议将其置于-80°C保存.
