N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 uM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.
产品描述
An inhibitor of SPHK and a natural metabolite of sphingosine in some cancer cell lines and tissues; inhibits SPHK from U937 cells with a Ki value of 3.1 uM