C-2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities， as do natural ceramides. These processes include differentiation of HL-60 cells， induction of apoptosis， activation of protein phosphatase 2A， and inhibition of the mitochondrial respiratory chain. C-2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C-2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.
产品描述
C-2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities， as do natural ceramides. These processes include differentiation of HL-60 cells，{2751} induction of apoptosis，{884} activation of protein phosphatase 2A，{2757} and inhibition of the mitochondrial respiratory chain.{5031} C-2 ceramide also enhances the expression of COX-2 in human dermal fibroblasts{2759} and stimulates the growth of bovine aortic smooth muscle cells.{3512} The ability of C-2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.{6012}
