Glial cell line-derived neurotrophic factor （GDNF） is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFR，which is a cell surface receptor for GDNF. The cDNA encoding GDNFR from human，rat，chicken and mouse have been cloned recently. GDNFR was also termed Ret ligand 1 （RETL1） or TGF-B-related neurotrophic factor receptor 1 （TrnR1） and nominated as GFR-1 recently. GFR-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase （PTK）. Thus，GDNF，GFR and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
Synthetic Peptide to amino acids 369-382 of human GFR-1
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的GFRalpha-1蛋白发生免疫反应.
保存建议
提供的GFRalpha-1抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该GFRalpha-1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
