This gene encodes a nuclear protein which is involved in cell cycle regulation. The encoded protein is a ubiquitin ligase capable of ubiquinating PCNP （PESTcontaining nuclear protein），and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain，a PHD finger，a set and ring associated （SRA） domain，and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants，some of which are nonprotein coding. [Provided by RefSeq，Feb 2012].
