Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPAR.gamma.. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPAR.gamma. agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-.DELTA.12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.
产品描述
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPAR.gamma..{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPAR.gamma. agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-.DELTA.12,14-PGJ2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}