The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse. Levels of DAT protein expression are altered by chronic drug administration. It has been shown that phosphorylation at Thr53 directly affects dopamine influx and amphetamine-stimulated substrate efflux, indicating that the Thr53 residue plays a major role in transport activity. Dopamine pT53 Antibody is ideal for researchers interested in neuroscience research.
应用类型
ELISA,Western Blot,
免疫原
Anti-Phospho-Thr53 Dopamine Transporter Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Thr53 of rat DAT conjugated to KLH.
来源宿主
Rabbit
反应性
Rattus (Rat)
保存建议
Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.
