【干冰】Anti-PI 3 Kinase p85 alpha pY607 (RABBIT) Antibody - 600-401-MR1-【干冰】Anti-PI 3 Kinase p85 alpha pY607 (RABBIT) Antibody

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背景资料: PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are responsible for coordinating a diverse range of cell functions, including proliferation and survival, and plays an important role in the metabolic actions of insulin, a mutation in this gene has been associated with insulin resistance. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. It is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Phosphatidylinositol 3-kinase plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. Anti-PI 3 Kinase p85 alpha pY607 Antibody is useful for researchers interested in studying Short Syndrome, Agammaglobulinemia 7 Autosomal Recessive, Gastric Cancer Research, and Interleukin-7 Signaling.

免疫原: Anti-PI 3 Kinase p85 alpha pY607 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Terminal portion of human PIK3R1 conjugated to Keyhole Limpet Hemocyanin (KLH).

保存建议: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。