SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1) is a transcriptional activator required for lipid homeostasis. It regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. It binds to the sterol regulatory element 1 (SRE-1) (5-ATCACCCCAC-3), which is a motif that is found in the promoter of the low-density lipoprotein receptor gene and other genes involved in sterol biosynthesis. SREBP1 has dual sequence specificity binding to both an E-box motif (5-ATCACGTGA-3) and to SRE-1 (5-ATCACCCCAC-3). Anti-SREBP1 Antibody is useful for researchers interested in Fatty Liver Disease, Smith-Magenis Syndrome, Adipogenesis, DNA binding transcription factor activity and chromatin binding.
应用类型
ELISA,Western Blot,
免疫原
Anti-SREBP1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a N-terminal portion of human SREBP1 conjugated to Keyhole Limpet Hemocyanin (KLH).
来源宿主
Rabbit
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
