- 中文名称
【干冰】Anti-SQSTM1/p62 (RABBIT) Antibody - 600-401-HB8
- 英文名字
- 【干冰】Anti-SQSTM1/p62 (RABBIT) Antibody - 600-401-HB8
- 供应商
- Rockland
- 产品货号
- 600-401-HB8
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- SQSTM1(Sequestosome 1)/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It functions as a bridge between polyubiquitinated cargo and autophagosomes and interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, SQSTM1 is involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) and is required to recruit ubiquitinated proteins to PML bodies in the nucleus. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and may play a role in titin/TTN downstream signaling in muscle cells. It is an adapter that mediates the interaction between TRAF6 and CYLD. SQSTM1 may be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. It is involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Mutations in this gene result in frontotemporal dementia and/or amyotrophic lateral sclerosis, and familial Paget disease of bone. Anti-SQSTM1 Antibody is useful for researchers interested in Cancer Research, Neuroscience, and Cytokines & Growth Factor Antibodies.
- 应用类型
- ELISA,Immunohistochemistry,IF Microscopy,Western Blot,
- 免疫原
- Anti-SQSTM1/p62 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human SQSTM1 conjugated to Keyhole Limpet Hemocyanin (KLH).
- 来源宿主
- Rabbit
- 反应性
- H. sapiens (Human); Mus musculus (Mouse)
- 保存建议
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。
- 注意
-
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