Polo-Like Kinase pS482/pS486/pS490 detects Polo-Like Kinase proteins. Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK. Anti-Polo-Like Kinase pS482/pS486/pS490 Antibody is ideal for investigators involved in Cell Cycle and Apoptosis research.
应用类型
Western Blot,
免疫原
Anti-Polo-like Kinase pS482/pS486/pS490 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser392482/486/490.
来源宿主
Rabbit
反应性
Xenopus
保存建议
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
