EphrinB Antibody detects EphrinB proteins which are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of EphrinB was phosphorylated in HEK293 cells after timulation by the soluble EphB2 receptor tyrosine kinase. Anti-EphrinB pY331 Antibody is ideal for investigators involved in Cell Migration, Cell Division, Cell Signaling and Neuroscience.
应用类型
ELISA,Western Blot,
免疫原
Anti-EphrinB pY331 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr331 Xenopus EphrinB conjugated to KLH.
来源宿主
Rabbit
反应性
Mus musculus (Mouse); Rattus (Rat)
保存建议
Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
