Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.
应用类型
ELISA,Immunohistochemistry,Western Blot,
免疫原
Anti-KPNA7 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide near the N-terminus of human KPNA7.
来源宿主
Rabbit
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
