Anti-HALLEN plays a role in the DNA damage response pathway by regulating post replication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links and DNA double-strand breaks sites on chromatin during DNA repair in response to stalled replication forks. Anti-HALLEN promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions. Anti-Hallen Antibody is useful for researchers interested in DNA damage and repair.
应用类型
ELISA,Western Blot,
免疫原
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 75-100 of Human Hallen. Hallen is a novel BRCT domain containing protein.
来源宿主
Rabbit
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
