BTB1 acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. It down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
应用类型
ELISA,Western Blot,
免疫原
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Human Btb1. Btb1 is a currently uncharacterized human ankyrin repeat protein BAA92655. This protein has been suggested to bind to CUL3.
来源宿主
Rabbit
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
