Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the alpha-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a，respectively. C5a binds to a signaling G-protein coupled receptor （GPCR） （C5aR/CD88），inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils，and induces release of histamine in basophils and mast cells.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Recombinant mouse C5a （Cat.# 4895A-20） can be used as a positive control. Other applications have not been determined.
免疫原
E. coli expressed mouse C5a
来源宿主
兔
反应性
经检测验证，可与小鼠种属来源的C5a蛋白发生免疫反应.
保存建议
提供的C5a抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该C5a抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
