Matrix metalloproteinases （MMPs） are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases，gelatinases，stromelysins，transmembrane MMPs，matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs，plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I，II，III，VII and X. MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
E. coli-expressed recombinant human MMP-1 （Cat.# 7781-10）
来源宿主
兔
反应性
经检测验证，可与人种属来源的MMP-1蛋白 发生免疫反应.
保存建议
提供的MMP-1抗体 产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该MMP-1抗体 产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
