Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently，Noggin has been shown to modulate the activities of other BMPs including BMP-2，-7，-13，and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely，transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation，reduced bone formation，and severe osteoporosis.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Recombinant human Noggin （Cat.# 4675-20） can be used as a positive control.
免疫原
E. coli expressed recombinant human Noggin
来源宿主
兔
反应性
经检测验证，可与人种属来源的Noggin蛋白发生免疫反应.
保存建议
提供的Noggin抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该Noggin抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
