Human IGF-BP5 is a cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells，fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality，reduced female fertility，whole body growth inhibition，and retarded muscle development.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Recombinant human IGFBP-5 （Cat.# 4723-25） can be used as a positive control. Other applications have not been determined.
免疫原
E. coli expressed human IGF-BP5
来源宿主
兔
反应性
经检测验证，可与人种属来源的IGF-BP5蛋白发生免疫反应.
保存建议
提供的IGF-BP5抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该IGF-BP5抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
