ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells，which is an essential step during normal lipid metabolism. It also binds with the LDL receptor （apo B/E）. Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms； E2，E3，and E4，which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Recombinant ApoA1 （Cat. # 4696-100） can be used as a positive control. The antibody recognizes ~34 kDa of human ApoE3. Reactivity to other species has not been tested.
免疫原
Recombinant human ApoE3
来源宿主
兔
反应性
经检测验证，可与人种属来源的ApoE3蛋白发生免疫反应.
保存建议
提供的ApoE3抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该ApoE3抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
