BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throμghout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name,BMPs initiate,promote and regulate bone development,growth,remodeling and repair. In vivo studies have shown that BMP-3 can independently induce cartilage formation.
应用类型
Western blot
免疫原
Synthetic peptide surrounding amino acid 369 of mouse BMP-3