TCR （T cell antigen receptor） recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. TCR is a heterodimer composed of either and B or γ and δ chains. The vast majority of circulating T cells （95%） express the /B heterodimer while roughly 2-5% express the γ/δ heterodimer. CD3 chains and the CD4 or CD8 coreceptors are also required for efficient signal transduction through the TCR.
应用类型
Western blotting （0.5-4 ug/ml）. Based on researcher’s feedback， it can also be used in immunoprecipitation （10-20 ug/ml）； and Immunohistochemistry （15-25 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes TCR in human sample， and to a lesser extent to mouse and rat samples. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 138 of human TCR
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的TCR alpha蛋白发生免疫反应.
保存建议
提供的TCR alpha抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该TCR alpha抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
