Human Histone Deacetylase 8 （HDAC8） is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy，osteodystrophy，neurodegenerative disorders，aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members，the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A （TSA）.
应用类型
Western blotting （1-5 ug/ml）. However， the optimal conditions should be determined individually. Reactivity to other species has not been tested.
