CXCR4 （fusin） is a member in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library. Its ligand is chemokine stroma-derived factor （SDF）. CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 through the viral envelope glycoprotein gp120. In other cases，CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells. A mouse monoclonal antibody （12G5） to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Blocking peptide （Cat.# 5541BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 18 of mouse CXCR4
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的CXCR4蛋白发生免疫反应.
保存建议
提供的CXCR4抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该CXCR4抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
