The X-linked zinc finger protein ZFX is a member of the Kruppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD),a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types,but it was dispensable for growth and differentiation of their progeny.
应用类型
Western Blot: 1 ug/ml, IHC: 5 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
ZFX antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ZFX.