SH3 and multiple ankyrin repeat domains 3 （SHANK3），a member of the Shank gene family，plays a role in synapse formation and dendritic spine maturation. Shank proteins （Shank 1-3） containing PDZ domains are scaffold proteins of the postsynaptic density （PSD） that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder （ASD） and the neurological symptoms of 22q13.3 deletion syndrome.
应用类型
Western Blot: 1 ug/ml， IHC: 2.5 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.
