The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1),also called embryonic ectoderm development,is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones,which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin B7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
应用类型
Western Blot: 1 - 2 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
EED antibody was raised against an 18 amino acid peptide near the amino terminus of human EED.