CRIM2，also known as Kielin/chordin-like protein （KCP），is a novel enhancer of BMP signaling. It binds to BMP7，a morphogen that is important for kidney development and part of the kidney’s physiological response to repair of acute kidney injury，enhancing its binding to its receptor. Because of this，CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-B1，suppressing activin- and TGF-B1-dependent transcription.
应用类型
Western Blot: 1 - 2 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
CRIM2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human CRIM2.
